What is Saxenda
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Saxenda (Liraglutide) is a prescription drug that helps obese or overweight adults lose weight and maintain weight loss. As an incretin mimetic that acts like glucagon-like peptide-1 (GLP-1), Saxenda helps regulate appetite and insulin levels.
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How Does Saxenda Work?
Saxenda mimics the action of GLP-1, targeting areas of the brain that regulate appetite and food intake. By activating GLP-1 receptors, Saxenda helps increase insulin secretion and reduce glucagon production.
It also slows gastric emptying which leads to a reduced appetite through a feeling of fullness. This effect helps patients achieve significant weight loss and better control their blood sugar levels.
What is Saxenda Used For?
Saxenda is used for the purpose of weight management. Here are the benefits of saxenda at a glance:
- Significant weight loss and maintenance
- Improved regulation of appetite
- Optimal insulin secretion and blood sugar control
How to Use Saxenda?
There are a few things you need to know to properly administer Saxenda:
How to take Saxenda?
Saxenda is administered using a pre-filled pen. It works as a subcutaneous injection.
Where to inject saxenda?
You have to inject Saxenda into the abdomen, thigh, or upper arm. Rotating the injection helps avoid any irritation.
What are the injection timings?
Saxenda can be taken at any time, with or without food, but it is best to take it at the same time each day.
Note: You will get optimal results if you follow your doctor's prescription and use the medication consistently. However, you must avoid injecting insulin and Saxenda together at the same site.
What is the Dosage of Saxenda?
Saxenda is a drug you should take exactly as prescribed by a health care professional.
Starting Dose: The typical starting dose is 0.6 mg injected once daily for the first week.
Incremental Increase: The dose is increased weekly until the target dose of 3.0 mg daily is reached.
Common Saxenda Dosages: 0.6 mg, 1.2 mg, 1.8 mg, 2.4 mg, and 3.0 mg.
Saxenda Side Effects
Taking Saxenda comes with certain side effects. Some are mild but other less common ones can be critical and you should immediately contact your healthcare provider.
Common Side Effects of Saxenda
- Diarrhea and constipation
- Vomiting
- Headache
- Injection site reactions like itchiness or rash
- Fatigue and dizziness
- Abdominal and upper abdominal pain
- Fever
Less Common Saxenda Side Effects
- Hypoglycemia (low blood sugar level)
- Acute pancreatitis
- Kidney problems
- Gastroenteritis (inflammation of the digestive system)
- Suicidal thoughts or actions
- Serious allergy reactions
Who Should Not Take Saxenda?
Do not use Saxenda if you have:
- A history of medullary thyroid carcinoma (MTC)
- A history of Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- Pancreatitis
- Kidney disease
- Gastroparesis
- Hypersensitivity reaction to liraglutide
- Pregnant individuals should also stay away from Saxenda.
It’s important that you talk to your doctor about your medical history before taking Saxenda to make sure it is safe for you.
Warnings & Precautions for Saxenda
Symptoms like a lump or swelling in your neck, hoarseness, difficulty swallowing, or shortness of breath are alarming. You must inform your doctor immediately. These could be signs of thyroid tumors, including thyroid cancer. These have been reported to be observed in animal studies with Saxenda. It's unknown if Saxenda causes thyroid cancer in humans.
Is Saxenda FDA Approved for Weight Loss?
Yes, Saxenda is FDA-approved for weight loss. It was approved in 2014 for chronic weight management in adults with a BMI of 30 kg/m2 or higher or a BMI of 27 kg/m2 or higher who have at least one weight-related condition, such as high blood pressure or type 2 diabetes. FDA later approved Saxenda (liraglutide) in 2020 for the treatment of obesity in adolescents aged 12 or older.
Administer Saxenda by subcutaneous injection into the abdomen, thigh, or upper arm once daily. Always use a new needle for each injection and follow your doctor's instructions regarding the dosage. Start with a low dose, which your doctor will gradually increase to minimize potential gastrointestinal side effects.